› 1pv3

Solution NMR

NMR Solution Structure of the Avian FAT-domain of Focal Adhesion Kinase

Released:
DOI: 10.2210/pdb1pv3/pdb
PDB entry 1pv3 coloured by chain, ensemble of 20 models, front view.
PDB entry 1pv3 coloured by chain, ensemble of 20 models, side view.
PDB entry 1pv3 coloured by chain, ensemble of 20 models, top view.
Source organism: Gallus gallus
Primary publication:
The focal adhesion targeting domain of focal adhesion kinase contains a hinge region that modulates tyrosine 926 phosphorylation.
Prutzman KC, Gao G, King ML, Iyer VV, Mueller GA, Schaller MD, Campbell SL
Structure 12 881-91 (2004)
PMID: 15130480

Function and Biology Details

Reaction catalysed: 
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169484 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Focal adhesion kinase 1 Chain: A
Molecule details ›
Chain: A
Length: 146 amino acids
Theoretical weight: 15.9 KDa
Source organism: Gallus gallus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q00944 (Residues: 920-1053; Coverage: 13%)
Gene names: FAK, FAK1, PTK2
Sequence domains: Focal adhesion targeting region
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

7 review citations

Focal adhesion kinase: in command and control of cell motility.
Mitra et al. (2005)
6 more

1 mention without citation

Defining the functional domain of programmed cell death 10 through its interactions with phosphatidylinositol-3,4,5-trisphosphate.
Dibble et al. (2010)