1pvh

X-ray diffraction
2.5Å resolution

Crystal structure of leukemia inhibitory factor in complex with gp130

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-147172 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Interleukin-6 receptor subunit beta Chains: A, C
Molecule details ›
Chains: A, C
Length: 201 amino acids
Theoretical weight: 23.07 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P40189 (Residues: 123-323; Coverage: 22%)
Gene name: IL6ST
Sequence domains:
Structure domains: Immunoglobulins
Leukemia inhibitory factor Chains: B, D
Molecule details ›
Chains: B, D
Length: 169 amino acids
Theoretical weight: 18.65 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: P15018 (Residues: 34-202; Coverage: 94%)
Gene names: HILDA, LIF
Sequence domains: LIF / OSM family
Structure domains: Growth Hormone; Chain: A;

Ligands and Environments

1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.1
Spacegroup: P212121
Unit cell:
a: 79.71Å b: 86.7Å c: 146.43Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.248 0.248 0.289
Expression system: Spodoptera frugiperda