› 1pw9

X-ray diffraction
1.6Å resolution

High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D

Released:
DOI: 10.2210/pdb1pw9/pdb
PDB entry 1pw9 coloured by chain, front view.
PDB entry 1pw9 coloured by chain, side view.
PDB entry 1pw9 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High-resolution structural insights into ligand binding and immune cell recognition by human lung surfactant protein D.
Shrive AK, Tharia HA, Strong P, Kishore U, Burns I, Rizkallah PJ, Reid KB, Greenhough TJ
J Mol Biol 331 509-23 (2003)
PMID: 12888356

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-152870 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Pulmonary surfactant-associated protein D Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 177 amino acids
Theoretical weight: 18.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P35247 (Residues: 199-375; Coverage: 50%)
Gene names: COLEC7, PSPD, SFTP4, SFTPD
Sequence domains:
Structure domains: Mannose-Binding Protein A, subunit A

Ligands and Environments

1 bound ligand:
Ligand CA 10 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX14.1
Spacegroup: P21
Unit cell:
a: 55.55Å b: 108.52Å c: 55.69Å
α: 90° β: 91.2° γ: 90°
R-values:
R R work R free
0.227 0.227 0.249
Expression system: Escherichia coli

Quick links

Citations

16 review citations

The C-type lectin-like domain superfamily.
Zelensky et al. (2005)
15 more

13 mentions without citation

Trimeric structure of langerin.
Feinberg et al. (2010)
12 more