› 1q1u

X-ray diffraction
1.7Å resolution

Crystal structure of human FHF1b (FGF12b)

Released:
DOI: 10.2210/pdb1q1u/pdb
PDB entry 1q1u coloured by chain, front view.
PDB entry 1q1u coloured by chain, side view.
PDB entry 1q1u coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs.
Olsen SK, Garbi M, Zampieri N, Eliseenkova AV, Ornitz DM, Goldfarb M, Mohammadi M
J Biol Chem 278 34226-36 (2003)
PMID: 12815063

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-158257 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 12 Chain: A
Molecule details ›
Chain: A
Length: 144 amino acids
Theoretical weight: 16.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P61328 (Residues: 67-206; Coverage: 58%)
Gene names: FGF12, FGF12B, FHF1
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

1 bound ligand:
Ligand SO4 4 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P212121
Unit cell:
a: 30.624Å b: 58.853Å c: 65.415Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.223 0.223 0.24
Expression system: Escherichia coli BL21

Quick links

Citations

53 review citations

The FGF family: biology, pathophysiology and therapy.
Beenken et al. (2009)
52 more

12 mentions without citation

Target-Based Small Molecule Drug Discovery for Colorectal Cancer: A Review of Molecular Pathways and In Silico Studies.
Moshawih et al. (2022)
11 more