› 1q3o

X-ray diffraction
1.8Å resolution

Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization

Released:
DOI: 10.2210/pdb1q3o/pdb
PDB entry 1q3o coloured by chain, front view.
PDB entry 1q3o coloured by chain, side view.
PDB entry 1q3o coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of the Shank PDZ-ligand complex reveals a class I PDZ interaction and a novel PDZ-PDZ dimerization.
Im YJ, Lee JH, Park SH, Park SJ, Rho SH, Kang GB, Kim E, Eom SH
J Biol Chem 278 48099-104 (2003)
PMID: 12954649

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194396 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
SH3 and multiple ankyrin repeat domains protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 109 amino acids
Theoretical weight: 12.07 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9WV48 (Residues: 654-762; Coverage: 5%)
Gene name: Shank1
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain

Ligands and Environments

1 bound ligand:
Ligand BR 5 x BR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PHOTON FACTORY BEAMLINE BL-18B
Spacegroup: P21
Unit cell:
a: 42Å b: 50.34Å c: 51.77Å
α: 90° β: 106.3° γ: 90°
R-values:
R R work R free
0.235 0.234 0.251
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

8 review citations

U2AF homology motifs: protein recognition in the RRM world.
Kielkopf et al. (2004)
7 more

7 mentions without citation

Electric-field-stimulated protein mechanics.
Hekstra et al. (2016)
6 more