› 1q8d

X-ray diffraction
1.8Å resolution

The crystal structure of GDNF family co-receptor alpha 1 domain 3

Released:
DOI: 10.2210/pdb1q8d/pdb
PDB entry 1q8d coloured by chain, front view.
PDB entry 1q8d coloured by chain, side view.
PDB entry 1q8d coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The structure of GFRalpha1 domain 3 reveals new insights into GDNF binding and RET activation.
Leppänen VM, Bespalov MM, Runeberg-Roos P, Puurand U, Merits A, Saarma M, Goldman A
EMBO J 23 1452-62 (2004)
PMID: 15044950

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178984 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GDNF family receptor alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 108 amino acids
Theoretical weight: 12.08 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62997 (Residues: 239-346; Coverage: 24%)
Gene names: Gdnfra, Gfra1, Retl1, Trnr1
Sequence domains: GDNF/GAS1 domain
Structure domains: GDNF binding domain

Ligands and Environments

1 bound ligand:
Ligand MPD 1 x MPD
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE BW7A
Spacegroup: P61
Unit cell:
a: 61.334Å b: 61.334Å c: 65.154Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.193 0.193 0.208
Expression system: Spodoptera frugiperda

Quick links

Citations

7 review citations

GDNF family receptor complexes are emerging drug targets.
Bespalov et al. (2007)
6 more

4 mentions without citation

Macromolecular ab initio phasing enforcing secondary and tertiary structure.
Millán et al. (2015)
3 more