› 1qby

Solution NMR

THE SOLUTION STRUCTURE OF A BAY-REGION 1R-BENZ[A]ANTHRACENE OXIDE ADDUCT AT THE N6 POSITION OF ADENINE OF AN OLIGODEOXYNUCLEOTIDE CONTAINING THE HUMAN N-RAS CODON 61 SEQUENCE

Released:
DOI: 10.2210/pdb1qby/pdb
PDB entry 1qby coloured by chain, front view.
PDB entry 1qby coloured by chain, side view.
PDB entry 1qby coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Intercalation of the (-)-(1R,2S,3R, 4S)-N6-[1-benz[a]anthracenyl]-2'-deoxyadenosyl adduct in an oligodeoxynucleotide containing the human N-ras codon 61 sequence.
Li Z, Mao H, Kim HY, Tamura PJ, Harris CM, Harris TM, Stone MP
Biochemistry 38 2969-81 (1999)
PMID: 10074349

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114428 (preferred)
Entry contents:
2 distinct DNA molecules
Macromolecules (2 distinct):
5'-D(*CP*GP*GP*AP*CP*(BZA)AP*AP*GP*AP*AP*G)-3' Chain: A
Molecule details ›
Chain: A
Length: 11 nucleotides
Theoretical weight: 3.42 KDa
Source organism: Synthetic construct
Expression system: Not provided
5'-D(*CP*TP*TP*CP*TP*TP*GP*TP*CP*CP* G)-3' Chain: B
Molecule details ›
Chain: B
Length: 11 nucleotides
Theoretical weight: 3.29 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand BZA 1 x BZA
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: NOE-RESTRAINED MOLECULAR DYNAMICS/SIMULATED ANNEALING
Expression system: Not provided

Quick links

Citations

3 review citations

Repair-Resistant DNA Lesions.
Geacintov et al. (2017)
2 more