› 1qcy

X-ray diffraction
2.3Å resolution

THE CRYSTAL STRUCTURE OF THE I-DOMAIN OF HUMAN INTEGRIN ALPHA1BETA1

Released:
DOI: 10.2210/pdb1qcy/pdb
PDB entry 1qcy coloured by chain, front view.
PDB entry 1qcy coloured by chain, side view.
PDB entry 1qcy coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Jararhagin-derived RKKH peptides induce structural changes in alpha1I domain of human integrin alpha1beta1.
Nymalm Y, Puranen JS, Nyholm TK, Käpylä J, Kidron H, Pentikäinen OT, Airenne TT, Heino J, Slotte JP, Johnson MS, Salminen TA
J Biol Chem 279 7962-70 (2004)
PMID: 14660600

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157417 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-1 Chain: A
Molecule details ›
Chain: A
Length: 193 amino acids
Theoretical weight: 21.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P56199 (Residues: 169-361; Coverage: 17%)
Gene name: ITGA1
Sequence domains: von Willebrand factor type A domain
Structure domains: von Willebrand factor, type A domain

Ligands and Environments

1 bound ligand:
Ligand MG 1 x MG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: C2
Unit cell:
a: 74.457Å b: 81.858Å c: 37.316Å
α: 90° β: 90.78° γ: 90°
R-values:
R R work R free
0.2 0.2 0.258
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Snake venom disintegrins: evolution of structure and function.
Calvete et al. (2005)
3 more

4 mentions without citation

In Situ Quantification of Surface Chemistry in Porous Collagen Biomaterials.
Tzeranis et al. (2016)
3 more