› 1qq2

X-ray diffraction
2.6Å resolution

CRYSTAL STRUCTURE OF A MAMMALIAN 2-CYS PEROXIREDOXIN, HBP23.

Released:
DOI: 10.2210/pdb1qq2/pdb
PDB entry 1qq2 coloured by chain, front view.
PDB entry 1qq2 coloured by chain, side view.
PDB entry 1qq2 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structure of a multifunctional 2-Cys peroxiredoxin heme-binding protein 23 kDa/proliferation-associated gene product.
Hirotsu S, Abe Y, Okada K, Nagahara N, Hori H, Nishino T, Hakoshima T
Proc Natl Acad Sci U S A 96 12333-8 (1999)
PMID: 10535922

Function and Biology Details

Reaction catalysed: 
Thioredoxin + ROOH = thioredoxin disulfide + H(2)O + ROH
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-179034 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peroxiredoxin-1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 199 amino acids
Theoretical weight: 22.12 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q63716 (Residues: 1-199; Coverage: 100%)
Gene names: Prdx1, Tdpx2
Sequence domains:
Structure domains: Glutaredoxin

Ligands and Environments

1 bound ligand:
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-C
Spacegroup: P41212
Unit cell:
a: 73.9Å b: 73.9Å c: 211.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.216 0.216 0.268
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Structure, mechanism and regulation of peroxiredoxins.
Wood et al. (2003)
38 more

24 mentions without citation

Typical 2-Cys peroxiredoxins--structures, mechanisms and functions.
Hall et al. (2009)
23 more