› 1qql

X-ray diffraction
2.3Å resolution

THE CRYSTAL STRUCTURE OF FIBROBLAST GROWTH FACTOR 7/1 CHIMERA

Released:
DOI: 10.2210/pdb1qql/pdb
PDB entry 1qql coloured by chain, front view.
PDB entry 1qql coloured by chain, side view.
PDB entry 1qql coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for interaction of FGF-1, FGF-2, and FGF-7 with different heparan sulfate motifs.
Ye S, Luo Y, Lu W, Jones RB, Linhardt RJ, Capila I, Toida T, Kan M, Pelletier H, McKeehan WL
Biochemistry 40 14429-39 (2001)
PMID: 11724555

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-169683 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Fibroblast growth factor 7 Chain: A
Molecule details ›
Chain: A
Length: 140 amino acids
Theoretical weight: 16.43 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q02195 (Residues: 55-194; Coverage: 85%)
Gene names: Fgf-7, Fgf7, Kgf
Sequence domains: Fibroblast growth factor
Structure domains: Trefoil (Acidic Fibroblast Growth Factor, subunit A)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F2
Spacegroup: P6422
Unit cell:
a: 89.8Å b: 89.8Å c: 65.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.262 0.237 0.328
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

25 review citations

Heparan sulfate proteoglycans.
Sarrazin et al. (2011)
24 more

2 mentions without citation

Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members.
Goetz et al. (2007)
1 more