› 1qr9

X-ray diffraction
1.6Å resolution

INHIBITION OF HIV-1 INFECTIVITY BY THE GP41 CORE: ROLE OF A CONSERVED HYDROPHOBIC CAVITY IN MEMBRANE FUSION

Released:
DOI: 10.2210/pdb1qr9/pdb
PDB entry 1qr9 coloured by chain, front view.
PDB entry 1qr9 coloured by chain, side view.
PDB entry 1qr9 coloured by chain, top view.
Source organism: Human immunodeficiency virus 1
Primary publication:
Inhibition of human immunodeficiency virus type 1 infectivity by the gp41 core: role of a conserved hydrophobic cavity in membrane fusion.
Ji H, Shu W, Burling FT, Jiang S, Lu M
J Virol 73 8578-86 (1999)
PMID: 10482611

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-181134 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
GP41 Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.84 KDa
Source organism: Human immunodeficiency virus 1
UniProt:
  • Canonical: Q76270 (Residues: 28-61; Coverage: 27%)
Gene name: HIV1 ENV
Structure domains: Helix Hairpins

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU200
Spacegroup: R3
Unit cell:
a: 49.675Å b: 49.675Å c: 60.195Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.202 0.202 0.261

Quick links

Citations

10 review citations

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41.
Lu et al. (2016)
9 more

4 mentions without citation

HIV-1 envelope glycoprotein structure.
Merk et al. (2013)
3 more