› 1qz6

X-ray diffraction
1.6Å resolution

Structure of rabbit actin in complex with jaspisamide A

Released:
DOI: 10.2210/pdb1qz6/pdb
PDB entry 1qz6 coloured by chain, front view.
PDB entry 1qz6 coloured by chain, side view.
PDB entry 1qz6 coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Trisoxazole macrolide toxins mimic the binding of actin-capping proteins to actin.
Klenchin VA, Allingham JS, King R, Tanaka J, Marriott G, Rayment I
Nat Struct Biol 10 1058-63 (2003)
PMID: 14578936

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159302 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecules (2 distinct):
Actin, alpha skeletal muscle Chain: A
Molecule details ›
Chain: A
Length: 375 amino acids
Theoretical weight: 41.88 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

Carbohydrate polymer : NEW Components: GLC, FRU
Carbohydrate polymer
3 bound ligands:
Ligand ATP 1 x ATP
Ligand JAS 1 x JAS
Ligand CA 1 x CA
1 modified residue:
Ligand HIC 1 x HIC

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 40.37Å b: 75.958Å c: 67.494Å
α: 90° β: 99.07° γ: 90°
R-values:
R R work R free
0.167 0.165 0.197

Quick links

Citations

14 review citations

Radiolytic protein footprinting with mass spectrometry to probe the structure of macromolecular complexes.
Takamoto et al. (2006)
13 more

3 mentions without citation

Crystal structures of monomeric actin bound to cytochalasin D.
Nair et al. (2008)
2 more