› 1qzp

Solution NMR

NMR structure of the human dematin headpiece domain

Released:
DOI: 10.2210/pdb1qzp/pdb
PDB entry 1qzp coloured by chain, ensemble of 13 models, front view.
PDB entry 1qzp coloured by chain, ensemble of 13 models, side view.
PDB entry 1qzp coloured by chain, ensemble of 13 models, top view.
Source organism: Homo sapiens
Primary publication:
The NMR structure of dematin headpiece reveals a dynamic loop that is conformationally altered upon phosphorylation at a distal site.
Frank BS, Vardar D, Chishti AH, McKnight CJ
J Biol Chem 279 7909-16 (2004)
PMID: 14660664

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170653 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Dematin Chain: A
Molecule details ›
Chain: A
Length: 68 amino acids
Theoretical weight: 7.94 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q08495 (Residues: 341-405; Coverage: 16%)
Gene names: DMT, DMTN, EPB49
Sequence domains: Villin headpiece domain
Structure domains: Villin headpiece domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Distance geometry / simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

3 review citations

Gene regulation by the glucocorticoid receptor: structure:function relationship.
Kumar et al. (2005)
2 more

2 mentions without citation

How to arm a supervillin: designing F-actin binding activity into supervillin headpiece.
Brown et al. (2009)
1 more