› 1r1z

X-ray diffraction
2.4Å resolution

The Crystal structure of the Carbohydrate recognition domain of the glycoprotein sorting receptor p58/ERGIC-53 reveals a novel metal binding site and conformational changes associated with calcium ion binding

Released:
DOI: 10.2210/pdb1r1z/pdb
PDB entry 1r1z coloured by chain, front view.
PDB entry 1r1z coloured by chain, side view.
PDB entry 1r1z coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
The crystal structure of the carbohydrate-recognition domain of the glycoprotein sorting receptor p58/ERGIC-53 reveals an unpredicted metal-binding site and conformational changes associated with calcium ion binding.
Velloso LM, Svensson K, Pettersson RF, Lindqvist Y
J Mol Biol 334 845-51 (2003)
PMID: 14643651

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-178979 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Protein ERGIC-53 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 263 amino acids
Theoretical weight: 29.03 KDa
Source organism: Rattus norvegicus
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: Q62902 (Residues: 43-284; Coverage: 50%)
Gene names: Ergic53, Lman1
Sequence domains: Legume-like lectin family
Structure domains: Jelly Rolls

Ligands and Environments

1 bound ligand:
Ligand CA 8 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P1
Unit cell:
a: 44.351Å b: 81.068Å c: 82.306Å
α: 91.05° β: 94.14° γ: 94.99°
R-values:
R R work R free
0.223 0.222 0.241
Expression system: Spodoptera frugiperda

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Citations

8 review citations

The COPII pathway and hematologic disease.
Khoriaty et al. (2012)
7 more

7 mentions without citation

Structural and functional diversity of the lectin repertoire in teleost fish: relevance to innate and adaptive immunity.
Vasta et al. (2011)
6 more