› 1r2q

X-ray diffraction
1.05Å resolution

Crystal Structure of Human Rab5a GTPase Domain at 1.05 A resolution

Released:
DOI: 10.2210/pdb1r2q/pdb
Model geometry
Fit model/data
PDB entry 1r2q coloured by chain, front view.
PDB entry 1r2q coloured by chain, side view.
PDB entry 1r2q coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Refinement of the structure of human Rab5a GTPase domain at 1.05 A resolution.
Terzyan S, Zhu G, Li G, Zhang XC
Acta Crystallogr D Biol Crystallogr 60 54-60 (2004)
PMID: 14684892

Function and Biology Details

Reaction catalysed: 
GTP + H(2)O = GDP + phosphate
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-148944 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ras-related protein Rab-5A Chain: A
Molecule details ›
Chain: A
Length: 170 amino acids
Theoretical weight: 18.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P20339 (Residues: 15-184; Coverage: 79%)
Gene names: RAB5, RAB5A
Sequence domains: Ras family
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:
Ligand MG 1 x MG
Ligand GNP 1 x GNP
Ligand GOL 6 x GOL
No modified residues

Experiments and Validation Details

wwPDB Validation report is not available for this entry.
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 35.727Å b: 64.573Å c: 66.18Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.125 0.124 0.169
Expression system: Escherichia coli BL21(DE3)

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Citations

2 citation in other articles

Structural basis of Rab5-Rabaptin5 interaction in endocytosis.
Zhu et al. (2004)
1 more

14 mentions without citation

Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains.
Kontis et al. (1997)
13 more