› 1r6f

X-ray diffraction
2.17Å resolution

The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague

Released:
DOI: 10.2210/pdb1r6f/pdb
PDB entry 1r6f coloured by chain, front view.
PDB entry 1r6f coloured by chain, side view.
PDB entry 1r6f coloured by chain, top view.
Source organism: Yersinia pestis
Primary publication:
The structure of Yersinia pestis V-antigen, an essential virulence factor and mediator of immunity against plague.
Derewenda U, Mateja A, Devedjiev Y, Routzahn KM, Evdokimov AG, Derewenda ZS, Waugh DS
Structure 12 301-6 (2004)
PMID: 14962390

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-143159 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Virulence-associated V antigen Chain: A
Molecule details ›
Chain: A
Length: 310 amino acids
Theoretical weight: 35.16 KDa
Source organism: Yersinia pestis
Expression system: Escherichia coli
UniProt:
  • Canonical: P0C7U7 (Residues: 24-326; Coverage: 93%)
Gene names: YPCD1.31c, YP_pCD52, icrV, lcrV, y0050, y5047
Sequence domains: V antigen (LcrV) protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9A
Spacegroup: P1
Unit cell:
a: 35.881Å b: 45.086Å c: 46.915Å
α: 76.2° β: 78.42° γ: 77.17°
R-values:
R R work R free
0.224 0.217 0.284
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells.
Galán et al. (2014)
25 more

18 mentions without citation

Surface organelles assembled by secretion systems of Gram-negative bacteria: diversity in structure and function.
Thanassi et al. (2012)
17 more