› 1r7w

Solution NMR

NMR STRUCTURE OF THE R(GGAGGACAUCCCUCACGGGUGACCGUGGUCCUCC), DOMAIN IV STEM-LOOP B OF ENTEROVIRAL IRES WITH AUCCCU BULGE

Released:
DOI: 10.2210/pdb1r7w/pdb
PDB entry 1r7w coloured by chain, ensemble of 20 models, front view.
PDB entry 1r7w coloured by chain, ensemble of 20 models, side view.
PDB entry 1r7w coloured by chain, ensemble of 20 models, top view.
Source organism: Synthetic construct
Primary publication:
NMR structures of loop B RNAs from the stem-loop IV domain of the enterovirus internal ribosome entry site: a single C to U substitution drastically changes the shape and flexibility of RNA.
Du Z, Ulyanov NB, Yu J, Andino R, James TL
Biochemistry 43 5757-71 (2004)
PMID: 15134450

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-196186 (preferred)
Entry contents:
1 distinct RNA molecule
Macromolecule:
34-MER Chain: A
Molecule details ›
Chain: A
Length: 34 nucleotides
Theoretical weight: 10.9 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: FULL MATRIX RELAXATION ANALYSIS OF NOE, RANDOM ERROR ANALYSIS OF NOE, SIMULATED ANNEALING USING RESTRAINED MOLECULAR DYNAMICS
Expression system: Not provided

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Citations

11 review citations

Structural insights into viral IRES-dependent translation mechanisms.
Lozano et al. (2015)
10 more