› 1rdw

X-ray diffraction
2.3Å resolution

Actin Crystal Dynamics: Structural Implications for F-actin Nucleation, Polymerization and Branching Mediated by the Anti-parallel Dimer

Released:
DOI: 10.2210/pdb1rdw/pdb
PDB entry 1rdw coloured by chain, front view.
PDB entry 1rdw coloured by chain, side view.
PDB entry 1rdw coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Actin crystal dynamics: structural implications for F-actin nucleation, polymerization, and branching mediated by the anti-parallel dimer.
Reutzel R, Yoshioka C, Govindasamy L, Yarmola EG, Agbandje-McKenna M, Bubb MR, McKenna R
J Struct Biol 146 291-301 (2004)
PMID: 15099571

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-159317 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Actin, alpha skeletal muscle Chain: X
Molecule details ›
Chain: X
Length: 375 amino acids
Theoretical weight: 41.86 KDa
Source organism: Oryctolagus cuniculus
Expression system: Not provided
UniProt:
  • Canonical: P68135 (Residues: 3-377; Coverage: 100%)
Gene names: ACTA, ACTA1
Sequence domains: Actin
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand MG 2 x MG
Ligand ATP 1 x ATP
Ligand LAR 1 x LAR
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P43212
Unit cell:
a: 100.917Å b: 100.917Å c: 103.871Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.162 0.162 0.224
Expression system: Not provided

Quick links

Citations

2 review citations

Nuclear actin extends, with no contraction in sight.
Pederson et al. (2005)
1 more

4 mentions without citation

Deep-Sea Sponges and Corals off the Western Coast of Florida-Intracellular Mechanisms of Action of Bioactive Compounds and Technological Advances Supporting the Drug Discovery Pipeline.
Iskandar et al. (2023)
3 more