› 1rgp

X-ray diffraction
2Å resolution

GTPASE-ACTIVATION DOMAIN FROM RHOGAP

Released:
DOI: 10.2210/pdb1rgp/pdb
PDB entry 1rgp coloured by chain, front view.
PDB entry 1rgp coloured by chain, side view.
PDB entry 1rgp coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The structure of the GTPase-activating domain from p50rhoGAP.
Barrett T, Xiao B, Dodson EJ, Dodson G, Ludbrook SB, Nurmahomed K, Gamblin SJ, Musacchio A, Smerdon SJ, Eccleston JF
Nature 385 458-61 (1997)
PMID: 9009196

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-170576 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Rho GTPase-activating protein 1 Chain: A
Molecule details ›
Chain: A
Length: 242 amino acids
Theoretical weight: 27.44 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q07960 (Residues: 198-439; Coverage: 55%)
Gene names: ARHGAP1, CDC42GAP, RHOGAP1
Sequence domains: RhoGAP domain
Structure domains: Rho GTPase activation protein

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X31
Spacegroup: P212121
Unit cell:
a: 36.086Å b: 70.086Å c: 79.205Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.22 0.22 0.283
Expression system: Escherichia coli

Quick links

Citations

13 review citations

Phosphoinositide kinases.
Fruman et al. (1998)
12 more

7 mentions without citation

Protein binding site prediction using an empirical scoring function.
Liang et al. (2006)
6 more