› 1rh7

X-ray diffraction
3.11Å resolution

Crystal Structure of Resistin-like beta

Released:
DOI: 10.2210/pdb1rh7/pdb
PDB entry 1rh7 coloured by chain, front view.
PDB entry 1rh7 coloured by chain, side view.
PDB entry 1rh7 coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Disulfide-dependent multimeric assembly of resistin family hormones.
Patel SD, Rajala MW, Rossetti L, Scherer PE, Shapiro L
Science 304 1154-8 (2004)
PMID: 15155948

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assemblies composition:
homo trimer (preferred)
homo hexamer
Assembly name:
PDBe Complex ID:
PDB-CPX-189370 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Resistin-like beta Chains: A, B, C, D, E, F
Molecule details ›
Chains: A, B, C, D, E, F
Length: 81 amino acids
Theoretical weight: 8.64 KDa
Source organism: Mus musculus
Expression system: Homo sapiens
UniProt:
  • Canonical: Q99P86 (Residues: 25-105; Coverage: 99%)
Gene names: Fizz2, Retnlb
Sequence domains: Resistin
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand PT 6 x PT
Ligand P6G 2 x P6G
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: I222
Unit cell:
a: 57.604Å b: 86.016Å c: 283.406Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.204 0.201 0.264
Expression system: Homo sapiens

Quick links

Citations

70 review citations

Adipokines in inflammation and metabolic disease.
Ouchi et al. (2011)
69 more

1 mention without citation

Resistin-like molecule β is a bactericidal protein that promotes spatial segregation of the microbiota and the colonic epithelium.
Propheter et al. (2017)