› 1rii

X-ray diffraction
1.7Å resolution

Crystal structure of phosphoglycerate mutase from M. Tuberculosis

Released:
DOI: 10.2210/pdb1rii/pdb
PDB entry 1rii coloured by chain, front view.
PDB entry 1rii coloured by chain, side view.
PDB entry 1rii coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
The 1.70 angstroms X-ray crystal structure of Mycobacterium tuberculosis phosphoglycerate mutase.
Müller P, Sawaya MR, Pashkov I, Chan S, Nguyen C, Wu Y, Perry LJ, Eisenberg D
Acta Crystallogr D Biol Crystallogr 61 309-15 (2005)
PMID: 15735341

Function and Biology Details

Reaction catalysed: 
(1a) [enzyme]-L-histidine + 2,3-bisphospho-D-glycerate = [enzyme]-N(tau)-phospho-L-histidine + 2/3-phospho-D-glycerate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161616 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 265 amino acids
Theoretical weight: 29 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WIC9 (Residues: 1-249; Coverage: 100%)
Gene names: MTCY20G9.15, Rv0489, gpm, gpm1, gpmA, pgm
Sequence domains: Histidine phosphatase superfamily (branch 1)
Structure domains: Phosphoglycerate mutase-like

Ligands and Environments

1 bound ligand:
Ligand GOL 5 x GOL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P21
Unit cell:
a: 58.914Å b: 136.79Å c: 65.929Å
α: 90° β: 97.78° γ: 90°
R-values:
R R work R free
0.221 not available 0.27
Expression system: Escherichia coli

Quick links

Citations

5 citation in other articles

Structural and biochemical studies of TIGAR (TP53-induced glycolysis and apoptosis regulator).
Li et al. (2009)
4 more

59 mentions without citation

Molecular basis of NF-κB signaling.
Napetschnig et al. (2013)
58 more