› 1rjt

Solution NMR

NMR Structure of CXC Chemokine CXCL11/ITAC

Released:
DOI: 10.2210/pdb1rjt/pdb
PDB entry 1rjt coloured by chain, ensemble of 10 models, front view.
PDB entry 1rjt coloured by chain, ensemble of 10 models, side view.
PDB entry 1rjt coloured by chain, ensemble of 10 models, top view.
Source organism: Homo sapiens
Primary publication:
NMR structure of CXCR3 binding chemokine CXCL11 (ITAC).
Booth V, Clark-Lewis I, Sykes BD
Protein Sci 13 2022-8 (2004)
PMID: 15273303

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127026 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-X-C motif chemokine 11 Chain: A
Molecule details ›
Chain: A
Length: 73 amino acids
Theoretical weight: 8.32 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14625 (Residues: 22-94; Coverage: 100%)
Gene names: CXCL11, ITAC, SCYB11, SCYB9B
Sequence domains: Small cytokines (intecrine/chemokine), interleukin-8 like
Structure domains: OB fold (Dihydrolipoamide Acetyltransferase, E2P)

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Not provided

Quick links

Citations

4 review citations

Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function.
Salanga et al. (2011)
3 more

11 mentions without citation

Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands.
Metzemaekers et al. (2017)
10 more