› 1rmj

Solution NMR

C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II

Released:
DOI: 10.2210/pdb1rmj/pdb
PDB entry 1rmj coloured by chain, ensemble of 20 models, front view.
PDB entry 1rmj coloured by chain, ensemble of 20 models, side view.
PDB entry 1rmj coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
C-terminal domain of insulin-like growth factor (IGF) binding protein-6: structure and interaction with IGF-II.
Headey SJ, Keizer DW, Yao S, Brasier G, Kantharidis P, Bach LA, Norton RS
Mol Endocrinol 18 2740-50 (2004)
PMID: 15308688

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-150253 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Insulin-like growth factor-binding protein 6 Chain: A
Molecule details ›
Chain: A
Length: 107 amino acids
Theoretical weight: 12.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P24592 (Residues: 161-240; Coverage: 38%)
Gene names: IBP6, IGFBP6
Sequence domains: Thyroglobulin type-1 repeat
Structure domains: Thyroglobulin type-1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing
Expression system: Escherichia coli BL21

Quick links

Citations

6 review citations

Molecular interactions of the IGF system.
Denley et al. (2005)
5 more

7 mentions without citation

Insulin-like growth factor system in cancer: novel targeted therapies.
Brahmkhatri et al. (2015)
6 more