› 1rmx

Solution NMR

A SHORT LEXITROPSIN THAT RECOGNIZES THE DNA MINOR GROOVE AT 5'-ACTAGT-3': UNDERSTANDING THE ROLE OF ISOPROPYL-THIAZOLE

Released:
DOI: 10.2210/pdb1rmx/pdb
PDB entry 1rmx coloured by chain, front view.
PDB entry 1rmx coloured by chain, side view.
PDB entry 1rmx coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
Short lexitropsin that recognizes the DNA minor groove at 5'-ACTAGT-3': understanding the role of isopropyl-thiazole.
Anthony NG, Johnston BF, Khalaf AI, MacKay SP, Parkinson JA, Suckling CJ, Waigh RD
J Am Chem Soc 126 11338-49 (2004)
PMID: 15355117

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-114526 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
5'-D(*CP*GP*AP*CP*TP*AP*GP*TP*CP*G)-3' Chains: A, B
Molecule details ›
Chains: A, B
Length: 10 nucleotides
Theoretical weight: 3.05 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand AIK 2 x AIK
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: Restrained Molecular Dynamics
Expression system: Not provided

Quick links

Citations

2 review citations

Minor groove binders as anti-infective agents.
Barrett et al. (2013)
1 more