› 1rq7

X-ray diffraction
2.6Å resolution

MYCOBACTERIUM TUBERCULOSIS FTSZ IN COMPLEX WITH GDP

Released:
DOI: 10.2210/pdb1rq7/pdb
PDB entry 1rq7 coloured by chain, front view.
PDB entry 1rq7 coloured by chain, side view.
PDB entry 1rq7 coloured by chain, top view.
Source organism: Mycobacterium tuberculosis
Primary publication:
Structure of Mycobacterium tuberculosis FtsZ reveals unexpected, G protein-like conformational switches.
Leung AK, Lucile White E, Ross LJ, Reynolds RC, DeVito JA, Borhani DW
J Mol Biol 342 953-70 (2004)
PMID: 15342249

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-161841 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein FtsZ Chains: A, B
Molecule details ›
Chains: A, B
Length: 382 amino acids
Theoretical weight: 39.07 KDa
Source organism: Mycobacterium tuberculosis
Expression system: Escherichia coli
UniProt:
  • Canonical: P9WN95 (Residues: 1-379; Coverage: 100%)
Gene names: MTCY270.18, Rv2150c, ftsZ
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand GDP 1 x GDP
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SIEMENS
Spacegroup: P65
Unit cell:
a: 88.619Å b: 88.619Å c: 179.196Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.184 0.242
Expression system: Escherichia coli

Quick links

Citations

16 review citations

Bacterial growth and cell division: a mycobacterial perspective.
Hett et al. (2008)
15 more

12 mentions without citation

Discovery of anti-TB agents that target the cell-division protein FtsZ.
Kumar et al. (2010)
11 more