Function and Biology Details
Reactions catalysed:
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)
Hydrolysis of four peptide bonds in the viral precursor polyprotein, commonly with Asp or Glu in the P6 position, Cys or Thr in P1 and Ser or Ala in P1'.
NTP + H(2)O = NDP + phosphate
ATP + H(2)O = ADP + phosphate
Biochemical function:
Biological process:
Cellular component:
- not assigned
Sequence domains:
Structure domain:
Structure analysis Details
Assembly composition:
hetero tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-128771 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Serine protease/helicase NS3
Molecule details ›
Chains: A, B
Length: 200 amino acids
Theoretical weight: 21.26 KDa
Source organism: Hepacivirus C
Expression system: Escherichia coli
UniProt:
Structure domains:
Length: 200 amino acids
Theoretical weight: 21.26 KDa
Source organism: Hepacivirus C
Expression system: Escherichia coli
UniProt:
- Canonical:
P26664 (Residues: 1027-1207; Coverage: 6%)
Structure domains:
Hepatitis C virus Non-structural protein NS4a domain-containing protein
Molecule details ›
Chains: C, D
Length: 23 amino acids
Theoretical weight: 2.39 KDa
Source organism: Hepacivirus C
Expression system: Not provided
UniProt:
Sequence domains: Hepatitis C virus non-structural protein NS4a
Length: 23 amino acids
Theoretical weight: 2.39 KDa
Source organism: Hepacivirus C
Expression system: Not provided
UniProt:
- Canonical: O39914 (Residues: 4-24; Coverage: 24%)
Sequence domains: Hepatitis C virus non-structural protein NS4a
