› 1rxt

X-ray diffraction
3Å resolution

Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase.

Released:
DOI: 10.2210/pdb1rxt/pdb
PDB entry 1rxt coloured by chain, front view.
PDB entry 1rxt coloured by chain, side view.
PDB entry 1rxt coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Yang J, Wang Y, Frey G, Abeles RH, Petsko GA, Ringe D

Function and Biology Details

Reaction catalysed: 
Tetradecanoyl-CoA + an N-terminal-glycyl-[protein] = CoA + an N-terminal-N-tetradecanoylglycyl-[protein]
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-151725 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycylpeptide N-tetradecanoyltransferase 1 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 496 amino acids
Theoretical weight: 56.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P30419 (Residues: 1-496; Coverage: 100%)
Gene names: NMT, NMT1
Sequence domains:
Structure domains: Aminopeptidase

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand CO 1 x CO
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P21
Unit cell:
a: 71.626Å b: 116.425Å c: 90.361Å
α: 90° β: 90.13° γ: 90°
R-values:
R R work R free
0.283 0.283 0.391
Expression system: Escherichia coli

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