› 1rzw

Solution NMR

The Solution Structure of the Archaeglobus fulgidis protein AF2095. Northeast Structural Genomics Consortium target GR4

Released:
DOI: 10.2210/pdb1rzw/pdb
PDB entry 1rzw coloured by chain, front view.
PDB entry 1rzw coloured by chain, side view.
PDB entry 1rzw coloured by chain, top view.
Source organism: Archaeoglobus fulgidus
Primary publication:
Solution structure of Archaeglobus fulgidis peptidyl-tRNA hydrolase (Pth2) provides evidence for an extensive conserved family of Pth2 enzymes in archea, bacteria, and eukaryotes.
Powers R, Mirkovic N, Goldsmith-Fischman S, Acton TB, Chiang Y, Huang YJ, Ma L, Rajan PK, Cort JR, Kennedy MA, Liu J, Rost B, Honig B, Murray D, Montelione GT
Protein Sci 14 2849-61 (2005)
PMID: 16251366

Function and Biology Details

Reaction catalysed: 
N-substituted aminoacyl-tRNA + H(2)O = N-substituted amino acid + tRNA
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-127987 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidyl-tRNA hydrolase Chain: A
Molecule details ›
Chain: A
Length: 123 amino acids
Theoretical weight: 13.58 KDa
Source organism: Archaeoglobus fulgidus
Expression system: Escherichia coli
UniProt:
  • Canonical: O28185 (Residues: 1-115; Coverage: 100%)
Gene names: AF_2095, pth
Sequence domains: Peptidyl-tRNA hydrolase PTH2
Structure domains: Bit1

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry simulated annealing molecular dynamics
Expression system: Escherichia coli

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Citations

1 review citation

Mosaic origin of the mitochondrial proteome.
Szklarczyk et al. (2010)
20 other articles

2 mentions without citation

Carboxylic ester hydrolases: Classification and database derived from their primary, secondary, and tertiary structures.
Chen et al. (2016)
1 more