› 1rzx

X-ray diffraction
2.1Å resolution

Crystal Structure of a Par-6 PDZ-peptide Complex

Released:
DOI: 10.2210/pdb1rzx/pdb
PDB entry 1rzx coloured by chain, front view.
PDB entry 1rzx coloured by chain, side view.
PDB entry 1rzx coloured by chain, top view.
Source organism: Drosophila melanogaster
Primary publication:
Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition.
Peterson FC, Penkert RR, Volkman BF, Prehoda KE
Mol Cell 13 665-76 (2004)
PMID: 15023337

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-132170 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
LD29223p Chain: A
Molecule details ›
Chain: A
Length: 98 amino acids
Theoretical weight: 10.5 KDa
Source organism: Drosophila melanogaster
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O97111 (Residues: 156-253; Coverage: 28%)
Gene names: CG5884, DPar-6, DPar6, Dm-Par-6, Dm-Par6, DmPAR-6, DmPar-6, DmPar6, Dmel\CG5884, Dmel_CG5884, Dmpar6, PAR-6, PAR6, Par, Par-6, Par6, dPAR-6, dPar-6, dmPar-6, par, par-6, par6
Sequence domains: PDZ domain
Structure domains: Pdz3 Domain
Acetylated VKESLV Peptide Chain: B
Molecule details ›
Chain: B
Length: 7 amino acids
Theoretical weight: 701 Da
Source organism: Drosophila melanogaster
Expression system: Not provided

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.2.2
Spacegroup: P63
Unit cell:
a: 64.853Å b: 64.853Å c: 52.599Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.22 0.22 0.27
Expression systems:
  • Escherichia coli BL21(DE3)
  • Not provided

Quick links

Citations

28 review citations

Rho GTPases: biochemistry and biology.
Jaffe et al. (2005)
27 more

11 mentions without citation

Plasticity of PDZ domains in ligand recognition and signaling.
Ivarsson Y. (2012)
10 more