› 1s1e

X-ray diffraction
2.3Å resolution

Crystal Structure of Kv Channel-interacting protein 1 (KChIP-1)

Released:
DOI: 10.2210/pdb1s1e/pdb
PDB entry 1s1e coloured by chain, front view.
PDB entry 1s1e coloured by chain, side view.
PDB entry 1s1e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Two N-terminal domains of Kv4 K(+) channels regulate binding to and modulation by KChIP1.
Scannevin RH, Wang K, Jow F, Megules J, Kopsco DC, Edris W, Carroll KC, Lü Q, Xu W, Xu Z, Katz AH, Olland S, Lin L, Taylor M, Stahl M, Malakian K, Somers W, Mosyak L, Bowlby MR, Chanda P, Rhodes KJ
Neuron 41 587-98 (2004)
PMID: 14980207

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192745 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Kv channel-interacting protein 1 Chain: A
Molecule details ›
Chain: A
Length: 224 amino acids
Theoretical weight: 26.34 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9NZI2 (Residues: 1-227; Coverage: 95%)
Gene names: KCHIP1, KCNIP1, VABP
Sequence domains:
Structure domains: EF-hand

Ligands and Environments

1 bound ligand:
Ligand CA 2 x CA
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P41212
Unit cell:
a: 50.133Å b: 50.133Å c: 177.329Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.252 0.224 0.273
Expression system: Escherichia coli BL21(DE3)

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Citations

23 review citations

Molecular physiology of cardiac repolarization.
Nerbonne et al. (2005)
22 more

8 mentions without citation

Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors.
Bähring R. (2018)
7 more