› 1s1s

X-ray diffraction
2.1Å resolution

Crystal Structure of ZipA in complex with indoloquinolizin 10b

Released:
DOI: 10.2210/pdb1s1s/pdb
PDB entry 1s1s coloured by chain, front view.
PDB entry 1s1s coloured by chain, side view.
PDB entry 1s1s coloured by chain, top view.
Source organism: Escherichia coli
Primary publication:
Design and synthesis of indolo[2,3-a]quinolizin-7-one inhibitors of the ZipA-FtsZ interaction.
Jennings LD, Foreman KW, Rush TS, Tsao DH, Mosyak L, Li Y, Sukhdeo MN, Ding W, Dushin EG, Kenny CH, Moghazeh SL, Petersen PJ, Ruzin AV, Tuckman M, Sutherland AG
Bioorg Med Chem Lett 14 1427-31 (2004)
PMID: 15006376

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-160124 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cell division protein ZipA Chains: A, B
Molecule details ›
Chains: A, B
Length: 144 amino acids
Theoretical weight: 16.13 KDa
Source organism: Escherichia coli
Expression system: Escherichia coli
UniProt:
  • Canonical: P77173 (Residues: 185-328; Coverage: 44%)
Gene names: JW2404, b2412, zipA
Sequence domains: ZipA, C-terminal FtsZ-binding domain
Structure domains: ZipA, C-terminal FtsZ-binding domain

Ligands and Environments

1 bound ligand:
Ligand WAC 1 x WAC
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21
Unit cell:
a: 52.446Å b: 38.847Å c: 71.515Å
α: 90° β: 106.28° γ: 90°
R-values:
R R work R free
0.226 0.226 0.28
Expression system: Escherichia coli

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Citations

17 review citations

Antituberculosis drugs: ten years of research.
Janin YL. (2007)
16 more

6 mentions without citation

Isatin and its derivatives: a survey of recent syntheses, reactions, and applications.
Varun et al. (2019)
5 more