1s3k

X-ray diffraction
1.9Å resolution

Crystal Structure of a Humanized Fab (hu3S193) in Complex with the Lewis Y Tetrasaccharide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
PDBe Complex ID:
PDB-CPX-233708 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (3 distinct):
HU3S193 Fab fragment, light chain Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.07 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins
HU3S193 Fab fragment, heavy chain Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 23.8 KDa
Source organism: Mus musculus
Expression system: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

Carbohydrate polymer : NEW Components: NDG, GAL, FUC
1 bound ligand:
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 14-BM-C
Spacegroup: P31
Unit cell:
a: 71.758Å b: 71.758Å c: 90.142Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.203 0.203 0.238
Expression system: Mus musculus