› 1s4w

Solution NMR

NMR structure of the cytoplasmic domain of integrin AIIb in DPC micelles

Released:
DOI: 10.2210/pdb1s4w/pdb
PDB entry 1s4w coloured by chain, ensemble of 20 models, front view.
PDB entry 1s4w coloured by chain, ensemble of 20 models, side view.
PDB entry 1s4w coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Vinogradova O, Vaynberg J, Kong X, Haas TA, Plow EF, Qin J
Proc Natl Acad Sci U S A 101 4094-9 (2004)
PMID: 15024114

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-140154 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Integrin alpha-IIb light chain, form 2 Chain: A
Molecule details ›
Chain: A
Length: 20 amino acids
Theoretical weight: 2.4 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P08514 (Residues: 1020-1039; Coverage: 2%)
Gene names: GP2B, ITGA2B, ITGAB
Sequence domains: Integrin alpha cytoplasmic region

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: hybrid distance geometry and dynamic simulated annealing
Expression system: Escherichia coli BL21(DE3)

Quick links

Citations

33 review citations

Structural basis of integrin regulation and signaling.
Luo et al. (2007)
32 more

5 mentions without citation

Membrane-mediated structural transitions at the cytoplasmic face during integrin activation.
Vinogradova et al. (2004)
4 more