› 1s8e

X-ray diffraction
2.3Å resolution

Crystal structure of Mre11-3

Released:
DOI: 10.2210/pdb1s8e/pdb
PDB entry 1s8e coloured by chain, front view.
PDB entry 1s8e coloured by chain, side view.
PDB entry 1s8e coloured by chain, top view.
Source organism: Pyrococcus furiosus DSM 3638
Primary publication:
Structural and functional analysis of Mre11-3.
Arthur LM, Gustausson K, Hopfner KP, Carson CT, Stracker TH, Karcher A, Felton D, Weitzman MD, Tainer J, Carney JP
Nucleic Acids Res 32 1886-93 (2004)
PMID: 15047855

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-186412 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DNA double-strand break repair protein Mre11 Chains: A, B
Molecule details ›
Chains: A, B
Length: 333 amino acids
Theoretical weight: 38.89 KDa
Source organism: Pyrococcus furiosus DSM 3638
Expression system: Escherichia coli
UniProt:
  • Canonical: Q8U1N9 (Residues: 1-333; Coverage: 78%)
Gene names: PF1166, mre11
Sequence domains: Calcineurin-like phosphoesterase
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MN 4 x MN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SSRL BEAMLINE BL9-1
Spacegroup: P212121
Unit cell:
a: 74.96Å b: 88.57Å c: 144.99Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.231 0.231 0.278
Expression system: Escherichia coli

Quick links

Citations

4 review citations

DNA end resection: many nucleases make light work.
Mimitou et al. (2009)
3 more

3 mentions without citation

Structural studies of DNA end detection and resection in homologous recombination.
Schiller et al. (2014)
2 more