› 1sbs

X-ray diffraction
2Å resolution

CRYSTAL STRUCTURE OF AN ANTI-HCG FAB

Released:
DOI: 10.2210/pdb1sbs/pdb
PDB entry 1sbs coloured by chain, front view.
PDB entry 1sbs coloured by chain, side view.
PDB entry 1sbs coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Structure of an Fab fragment against a C-terminal peptide of hCG at 2.0 A resolution.
Fotinou C, Beauchamp J, Emsley P, deHaan A, Schielen WJ, Bos E, Isaacs NW
J Biol Chem 273 22515-8 (1998)
PMID: 9712877

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero tetramer
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-226421 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
MONOCLONAL ANTIBODY 3A2 Chain: H
Molecule details ›
Chain: H
Length: 222 amino acids
Theoretical weight: 24.13 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
MONOCLONAL ANTIBODY 3A2 Chain: L
Molecule details ›
Chain: L
Length: 220 amino acids
Theoretical weight: 24.43 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand SO4 1 x SO4
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SRS BEAMLINE PX9.5
Spacegroup: P3121
Unit cell:
a: 74.8Å b: 74.8Å c: 198.205Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.18 0.18 0.24

Quick links

Citations

2 review citations

The role of prostaglandins and other eicosanoids in the gastrointestinal tract.
Wang et al. (2005)
1 more

3 mentions without citation

Exchanging murine and human immunoglobulin constant chains affects the kinetics and thermodynamics of antigen binding and chimeric antibody autoreactivity.
Torres et al. (2007)
2 more