› 1sd3

X-ray diffraction
1.8Å resolution

Crystal structure of the GLUR6 ligand binding core in complex with 2S,4R-4-methylglutamate at 1.8 Angstrom resolution

Released:
DOI: 10.2210/pdb1sd3/pdb
PDB entry 1sd3 coloured by chain, front view.
PDB entry 1sd3 coloured by chain, side view.
PDB entry 1sd3 coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity.
Mayer ML
Neuron 45 539-52 (2005)
PMID: 15721240

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154587 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glutamate receptor ionotropic, kainate 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 259 amino acids
Theoretical weight: 29.37 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P42260 (Residues: 429-544, 667-806; Coverage: 29%)
Gene names: Glur6, Grik2
Sequence domains:
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

1 bound ligand:
Ligand SYM 2 x SYM
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X9B
Spacegroup: P212121
Unit cell:
a: 57.742Å b: 91.254Å c: 105.552Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.225 0.223 0.256
Expression system: Escherichia coli

Quick links

Citations

39 review citations

Glutamate receptor ion channels: structure, regulation, and function.
Traynelis et al. (2010)
38 more

3 mentions without citation

Allosteric control of an ionotropic glutamate receptor with an optical switch.
Volgraf et al. (2006)
2 more