› 1sdd

X-ray diffraction
2.8Å resolution

Crystal Structure of Bovine Factor Vai

Released:
DOI: 10.2210/pdb1sdd/pdb
PDB entry 1sdd coloured by chain, front view.
PDB entry 1sdd coloured by chain, side view.
PDB entry 1sdd coloured by chain, top view.
Source organism: Bos taurus
Primary publication:
The crystal structure of activated protein C-inactivated bovine factor Va: Implications for cofactor function.
Adams TE, Hockin MF, Mann KG, Everse SJ
Proc Natl Acad Sci U S A 101 8918-23 (2004)
PMID: 15184653

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-173305 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Coagulation factor V heavy chain Chain: A
Molecule details ›
Chain: A
Length: 306 amino acids
Theoretical weight: 34.73 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q28107 (Residues: 29-334; Coverage: 14%)
Gene name: F5
Sequence domains: Multicopper oxidase
Structure domains: Cupredoxins - blue copper proteins
Coagulation factor V light chain Chain: B
Molecule details ›
Chain: B
Length: 647 amino acids
Theoretical weight: 74.71 KDa
Source organism: Bos taurus
UniProt:
  • Canonical: Q28107 (Residues: 1565-2211; Coverage: 30%)
Gene name: F5
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand NAG 5 x NAG
Ligand CA 1 x CA
Ligand CU 1 x CU
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE A1, NSLS BEAMLINE X12C, NSLS BEAMLINE X25
Spacegroup: P212121
Unit cell:
a: 63.37Å b: 86.56Å c: 229.2Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.258 0.252 0.296

Quick links

Citations

15 review citations

Regulation of blood coagulation by the protein C anticoagulant pathway: novel insights into structure-function relationships and molecular recognition.
Dahlbäck et al. (2005)
14 more

13 mentions without citation

Uncovering Membrane-Bound Models of Coagulation Factors by Combined Experimental and Computational Approaches.
Ohkubo et al. (2021)
12 more