› 1sg0

X-ray diffraction
1.5Å resolution

Crystal structure analysis of QR2 in complex with resveratrol

Released:
DOI: 10.2210/pdb1sg0/pdb
PDB entry 1sg0 coloured by chain, front view.
PDB entry 1sg0 coloured by chain, side view.
PDB entry 1sg0 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of quinone reductase 2 in complex with resveratrol.
Buryanovskyy L, Fu Y, Boyd M, Ma Y, Hsieh TC, Wu JM, Zhang Z
Biochemistry 43 11417-26 (2004)
PMID: 15350128

Function and Biology Details

Reaction catalysed: 
1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a quinol
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-147595 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ribosyldihydronicotinamide dehydrogenase [quinone] Chains: A, B
Molecule details ›
Chains: A, B
Length: 230 amino acids
Theoretical weight: 25.85 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P16083 (Residues: 2-231; Coverage: 100%)
Gene names: NMOR2, NQO2
Sequence domains: Flavodoxin-like fold
Structure domains: Rossmann fold

Ligands and Environments


Cofactor: Ligand FAD 2 x FAD
2 bound ligands:
Ligand ZN 2 x ZN
Ligand STL 2 x STL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-BM
Spacegroup: P212121
Unit cell:
a: 83.33Å b: 106.372Å c: 56.982Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.226 0.214 0.234
Expression system: Escherichia coli

Quick links

Citations

37 review citations

Therapeutic potential of resveratrol: the in vivo evidence.
Baur et al. (2006)
36 more

22 mentions without citation

Polypharmacology or Promiscuity? Structural Interactions of Resveratrol With Its Bandwagon of Targets.
Saqib et al. (2018)
21 more