› 1sou

Solution NMR

NMR structure of Aquifex aeolicus 5,10-methenyltetrahydrofolate synthetase: Northeast Structural Genomics Consortium Target QR46

Released:
DOI: 10.2210/pdb1sou/pdb
PDB entry 1sou coloured by chain, ensemble of 20 models, front view.
PDB entry 1sou coloured by chain, ensemble of 20 models, side view.
PDB entry 1sou coloured by chain, ensemble of 20 models, top view.
Source organism: Aquifex aeolicus
Entry authors: Cort JR, Chiang Y, Acton T, Wu M, Montelione GT, Kennedy MA, Northeast Structural Genomics Consortium (NESG)

Function and Biology Details

Reaction catalysed: 
ATP + 5-formyltetrahydrofolate = ADP + phosphate + 5,10-methenyltetrahydrofolate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-130521 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
5-formyltetrahydrofolate cyclo-ligase Chain: A
Molecule details ›
Chain: A
Length: 194 amino acids
Theoretical weight: 22.36 KDa
Source organism: Aquifex aeolicus
Expression system: Escherichia coli
UniProt:
  • Canonical: O67621 (Residues: 1-186; Coverage: 100%)
Gene name: aq_1731
Sequence domains: 5-formyltetrahydrofolate cyclo-ligase family
Structure domains: NagB/RpiA/CoA transferase-like

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: MOLECULAR DYNAMICS, SIMULATED ANNEALING
Expression system: Escherichia coli

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