› 1ss6

Solution NMR

Solution structure of SEP domain from human p47

Released:
DOI: 10.2210/pdb1ss6/pdb
PDB entry 1ss6 coloured by chain, ensemble of 20 models, front view.
PDB entry 1ss6 coloured by chain, ensemble of 20 models, side view.
PDB entry 1ss6 coloured by chain, ensemble of 20 models, top view.
Source organism: Homo sapiens
Primary publication:
The SEP domain of p47 acts as a reversible competitive inhibitor of cathepsin L.
Soukenik M, Diehl A, Leidert M, Sievert V, Büssow K, Leitner D, Labudde D, Ball LJ, Lechner A, Nägler DK, Oschkinat H
FEBS Lett 576 358-62 (2004)
PMID: 15498563

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194022 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
NSFL1 cofactor p47 Chain: A
Molecule details ›
Chain: A
Length: 102 amino acids
Theoretical weight: 11.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9UNZ2 (Residues: 171-270; Coverage: 27%)
Gene names: NSFL1C, UBXN2C
Sequence domains: SEP domain
Structure domains: SEP domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: distance geometry
Expression system: Escherichia coli

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Citations

1 review citation

UBXD Proteins: A Family of Proteins with Diverse Functions in Cancer.
Rezvani K. (2016)
9 other articles

6 mentions without citation

Versatile control of the CDC48 segregase by the plant UBX-containing (PUX) proteins.
Zhang et al. (2021)
5 more