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Solution NMR

Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein

Released:
DOI: 10.2210/pdb1ssk/pdb
PDB entry 1ssk coloured by chain, front view.
PDB entry 1ssk coloured by chain, side view.
PDB entry 1ssk coloured by chain, top view.
Source organism: Severe acute respiratory syndrome-related coronavirus
Primary publication:
Structure of the N-terminal RNA-binding domain of the SARS CoV nucleocapsid protein.
Huang Q, Yu L, Petros AM, Gunasekera A, Liu Z, Xu N, Hajduk P, Mack J, Fesik SW, Olejniczak ET
Biochemistry 43 6059-63 (2004)
PMID: 15147189

Function and Biology Details

Biochemical function:
Biological process:
  • not assigned
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-157822 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Nucleoprotein Chain: A
Molecule details ›
Chain: A
Length: 158 amino acids
Theoretical weight: 17.18 KDa
Source organism: Severe acute respiratory syndrome-related coronavirus
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P59595 (Residues: 44-181; Coverage: 33%)
Gene names: 9a, N
Sequence domains: Coronavirus nucleocapsid

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21

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Citations

29 review citations

The molecular biology of coronaviruses.
Masters PS. (2006)
28 more

38 mentions without citation

From SARS to MERS: 10 years of research on highly pathogenic human coronaviruses.
Hilgenfeld et al. (2013)
37 more