Function and Biology Details
Reaction catalysed:
Hydrolysis of proteins with broad specificity for peptide bonds, but preference for an amino acid bearing a large hydrophobic side chain at the P2 position. Does not accept Val in P1'.
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:
Structure analysis Details
Assembly composition:
hetero dimer (preferred)
Assembly name:
Cystatin-B and Papain (preferred)
PDBe Complex ID:
PDB-CPX-133540 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Papain
Molecule details ›
Chain: E
Length: 212 amino acids
Theoretical weight: 23.51 KDa
Source organism: Carica papaya
Expression system: Escherichia coli
UniProt:
Structure domains: Cysteine proteinases
Length: 212 amino acids
Theoretical weight: 23.51 KDa
Source organism: Carica papaya
Expression system: Escherichia coli
UniProt:
- Canonical:
P00784 (Residues: 134-345; Coverage: 65%)
Structure domains: Cysteine proteinases
Cystatin-B
Molecule details ›
Chain: I
Length: 98 amino acids
Theoretical weight: 11.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,
Length: 98 amino acids
Theoretical weight: 11.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
- Canonical: P04080 (Residues: 1-98; Coverage: 100%)
Sequence domains: Cystatin domain
Structure domains: Nuclear Transport Factor 2; Chain: A,
