› 1sux

X-ray diffraction
2Å resolution

CRYSTALLOGRAPHIC ANALYSIS OF THE COMPLEX BETWEEN TRIOSEPHOSPHATE ISOMERASE FROM TRYPANOSOMA CRUZI AND 3-(2-benzothiazolylthio)-1-propanesulfonic acid

Released:
DOI: 10.2210/pdb1sux/pdb
PDB entry 1sux coloured by chain, front view.
PDB entry 1sux coloured by chain, side view.
PDB entry 1sux coloured by chain, top view.
Source organism: Trypanosoma cruzi
Primary publication:
Inactivation of triosephosphate isomerase from Trypanosoma cruzi by an agent that perturbs its dimer interface.
Téllez-Valencia A, Olivares-Illana V, Hernández-Santoyo A, Pérez-Montfort R, Costas M, Rodríguez-Romero A, López-Calahorra F, Tuena De Gómez-Puyou M, Gómez-Puyou A
J Mol Biol 341 1355-65 (2004)
PMID: 15321726

Function and Biology Details

Reaction catalysed: 
D-glyceraldehyde 3-phosphate = glycerone phosphate
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156485 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Triosephosphate isomerase, glycosomal Chains: A, B
Molecule details ›
Chains: A, B
Length: 251 amino acids
Theoretical weight: 27.36 KDa
Source organism: Trypanosoma cruzi
Expression system: Escherichia coli
UniProt:
  • Canonical: P52270 (Residues: 1-251; Coverage: 100%)
Sequence domains: Triosephosphate isomerase
Structure domains: Aldolase class I

Ligands and Environments

2 bound ligands:
Ligand SO4 7 x SO4
Ligand BTS 1 x BTS
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P212121
Unit cell:
a: 42.87Å b: 75.58Å c: 146.45Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.183 0.183 0.196
Expression system: Escherichia coli

Quick links

Citations

4 review citations

Triosephosphate isomerase: a highly evolved biocatalyst.
Wierenga et al. (2010)
3 more

3 mentions without citation

Copaifera of the Neotropics: A Review of the Phytochemistry and Pharmacology.
da Trindade et al. (2018)
2 more