› 1swx

X-ray diffraction
1.65Å resolution

Crystal structure of a human glycolipid transfer protein in apo-form

Released:
DOI: 10.2210/pdb1swx/pdb
PDB entry 1swx coloured by chain, front view.
PDB entry 1swx coloured by chain, side view.
PDB entry 1swx coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Structural basis for glycosphingolipid transfer specificity.
Malinina L, Malakhova ML, Teplov A, Brown RE, Patel DJ
Nature 430 1048-53 (2004)
PMID: 15329726

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-192739 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Glycolipid transfer protein Chain: A
Molecule details ›
Chain: A
Length: 209 amino acids
Theoretical weight: 23.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9NZD2 (Residues: 1-209; Coverage: 100%)
Gene name: GLTP
Sequence domains: Glycolipid transfer protein (GLTP)
Structure domains: Glycolipid transfer protein

Ligands and Environments

1 bound ligand:
Ligand HEX 1 x HEX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RUH3R, APS BEAMLINE 19-BM
Spacegroup: P21
Unit cell:
a: 55.439Å b: 35.259Å c: 57.507Å
α: 90° β: 115.82° γ: 90°
R-values:
R R work R free
0.175 0.172 0.226
Expression system: Escherichia coli

Quick links

Citations

26 review citations

Principles of lysosomal membrane digestion: stimulation of sphingolipid degradation by sphingolipid activator proteins and anionic lysosomal lipids.
Kolter et al. (2005)
25 more

12 mentions without citation

K+ channel modulators for the treatment of neurological disorders and autoimmune diseases.
Wulff et al. (2008)
11 more