› 1t3s

X-ray diffraction
2.3Å resolution

Structural Analysis of the Voltage-Dependent Calcium Channel Beta Subunit Functional Core

Released:
DOI: 10.2210/pdb1t3s/pdb
PDB entry 1t3s coloured by chain, front view.
PDB entry 1t3s coloured by chain, side view.
PDB entry 1t3s coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Structural analysis of the voltage-dependent calcium channel beta subunit functional core and its complex with the alpha 1 interaction domain.
Opatowsky Y, Chen CC, Campbell KP, Hirsch JA
Neuron 42 387-99 (2004)
PMID: 15134636

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156985 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Voltage-dependent L-type calcium channel subunit beta-2 Chain: A
Molecule details ›
Chain: A
Length: 337 amino acids
Theoretical weight: 38.34 KDa
Source organism: Oryctolagus cuniculus
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P54288 (Residues: 51-448; Coverage: 53%)
Gene names: CACNB2, CACNLB2
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand HG 1 x HG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-2
Spacegroup: P21212
Unit cell:
a: 74.066Å b: 163.841Å c: 34.761Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.262 0.261 0.277
Expression system: Escherichia coli BL21(DE3)

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Citations

60 review citations

The Physiology, Pathology, and Pharmacology of Voltage-Gated Calcium Channels and Their Future Therapeutic Potential.
Zamponi et al. (2015)
59 more

7 mentions without citation

In Vivo, Proteomic, and In Silico Investigation of Sapodilla for Therapeutic Potential in Gastrointestinal Disorders.
Ansari et al. (2019)
6 more