› 1t4k

X-ray diffraction
2.5Å resolution

Crystal Structure of Unliganded Aldolase Antibody 93F3 Fab

Released:
DOI: 10.2210/pdb1t4k/pdb
PDB entry 1t4k coloured by chain, front view.
PDB entry 1t4k coloured by chain, side view.
PDB entry 1t4k coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis.
Zhu X, Tanaka F, Hu Y, Heine A, Fuller R, Zhong G, Olson AJ, Lerner RA, Barbas CF, Wilson IA
J Mol Biol 343 1269-80 (2004)
PMID: 15491612

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-213095 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
IMMUNOGLOBULIN IGG1, KAPPA LIGHT CHAIN Chains: A, C
Molecule details ›
Chains: A, C
Length: 217 amino acids
Theoretical weight: 24.1 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins
IMMUNOGLOBULIN IGG1, HEAVY CHAIN Chains: B, D
Molecule details ›
Chains: B, D
Length: 217 amino acids
Theoretical weight: 22.84 KDa
Source organism: Mus musculus
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand ZN 9 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 5.0.2
Spacegroup: P212121
Unit cell:
a: 79.701Å b: 81.228Å c: 149.496Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.233 0.233 0.281

Quick links

Citations

2 review citations

Chemically programmed antibodies.
Rader C. (2014)
1 more

5 mentions without citation

Using cross-species vaccination approaches to counter emerging infectious diseases.
Warimwe et al. (2021)
4 more