› 1t4r

X-ray diffraction
2.6Å resolution

arginase-descarboxy-nor-NOHA complex

Released:
DOI: 10.2210/pdb1t4r/pdb
PDB entry 1t4r coloured by chain, front view.
PDB entry 1t4r coloured by chain, side view.
PDB entry 1t4r coloured by chain, top view.
Source organism: Rattus norvegicus
Primary publication:
Inhibitor coordination interactions in the binuclear manganese cluster of arginase.
Cama E, Pethe S, Boucher JL, Han S, Emig FA, Ash DE, Viola RE, Mansuy D, Christianson DW
Biochemistry 43 8987-99 (2004)
PMID: 15248756

Function and Biology Details

Reaction catalysed: 
L-arginine + H(2)O = L-ornithine + urea
Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo trimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139779 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arginase-1 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 314 amino acids
Theoretical weight: 34.03 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli
UniProt:
  • Canonical: P07824 (Residues: 6-319; Coverage: 97%)
Gene name: Arg1
Sequence domains: Arginase family
Structure domains: Ureohydrolase domain

Ligands and Environments

2 bound ligands:
Ligand MN 6 x MN
Ligand AHI 3 x AHI
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P32
Unit cell:
a: 88.3Å b: 88.3Å c: 113.2Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.255 0.255 0.291
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Targeting Metalloenzymes for Therapeutic Intervention.
Chen et al. (2019)
6 more

1 mention without citation

Evolution of the Banana Genome (Musa acuminata) Is Impacted by Large Chromosomal Translocations.
Martin et al. (2017)