› 1t5m

Solution NMR

Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin

Released:
DOI: 10.2210/pdb1t5m/pdb
PDB entry 1t5m coloured by chain, ensemble of 15 models, front view.
PDB entry 1t5m coloured by chain, ensemble of 15 models, side view.
PDB entry 1t5m coloured by chain, ensemble of 15 models, top view.
Source organism: Streptomyces filamentosus
Primary publication:
Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin.
Jung D, Rozek A, Okon M, Hancock RE
Chem Biol 11 949-57 (2004)
PMID: 15271353

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-162458 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
DAPTOMYCIN Chain: A
Molecule details ›
Chain: A
Length: 13 amino acids
Theoretical weight: 1.48 KDa
Source organism: Streptomyces filamentosus
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand DKA 1 x DKA
6 modified residues:
Ligand DSG 1 x DSG
Ligand ORN 1 x ORN
Ligand DAL 1 x DAL
Ligand DSN 1 x DSN
Ligand LME 1 x LME
Ligand KYN 1 x KYN

Experiments and Validation Details

Entry percentile scores
Expression system: Not provided

Quick links

Citations

45 review citations

Natural products to drugs: natural product derived compounds in clinical trials.
Butler MS. (2005)
44 more

2 mentions without citation

Phospholipid translocation captured in a bifunctional membrane protein MprF.
Song et al. (2021)
1 more