› 1t77

X-ray diffraction
2.4Å resolution

Crystal structure of the PH-BEACH domains of human LRBA/BGL

Released:
DOI: 10.2210/pdb1t77/pdb
PDB entry 1t77 coloured by chain, front view.
PDB entry 1t77 coloured by chain, side view.
PDB entry 1t77 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Crystal structure of the PH-BEACH domains of human LRBA/BGL.
Gebauer D, Li J, Jogl G, Shen Y, Myszka DG, Tong L
Biochemistry 43 14873-80 (2004)
PMID: 15554694

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-156265 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lipopolysaccharide-responsive and beige-like anchor protein Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 414 amino acids
Theoretical weight: 47.71 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50851 (Residues: 2076-2489; Coverage: 15%)
Gene names: BGL, CDC4L, LBA, LRBA
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4A
Spacegroup: P21
Unit cell:
a: 73.218Å b: 102.239Å c: 131.519Å
α: 90° β: 90.47° γ: 90°
R-values:
R R work R free
0.22 0.21 0.258
Expression system: Escherichia coli

Quick links

Citations

10 review citations

Chediak-Higashi syndrome.
Kaplan et al. (2008)
9 more

4 mentions without citation

Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.
van Schouwenburg et al. (2015)
3 more