› 1t9k

X-ray diffraction
2.6Å resolution

X-ray crystal structure of aIF-2B alpha subunit-related translation initiation factor [Thermotoga maritima]

Released:
DOI: 10.2210/pdb1t9k/pdb
PDB entry 1t9k coloured by chain, front view.
PDB entry 1t9k coloured by chain, side view.
PDB entry 1t9k coloured by chain, top view.
Source organism: Thermotoga maritima
Entry authors: Osipiuk J, Skarina T, Savchenko A, Edwards A, Cymborowski M, Minor W, Joachimiak A, Midwest Center for Structural Genomics (MCSG)

Function and Biology Details

Reaction catalysed: 
S-methyl-5-thio-alpha-D-ribose 1-phosphate = S-methyl-5-thio-D-ribulose 1-phosphate
Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-194665 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Methylthioribose-1-phosphate isomerase Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 347 amino acids
Theoretical weight: 38.86 KDa
Source organism: Thermotoga maritima
Expression system: Escherichia coli
UniProt:
  • Canonical: Q9X013 (Residues: 1-343; Coverage: 100%)
Gene names: TM_0911, mtnA
Sequence domains: Initiation factor 2 subunit family
Structure domains:

Ligands and Environments

2 bound ligands:
Ligand SO4 4 x SO4
Ligand CL 2 x CL
1 modified residue:
Ligand MSE 36 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P3121
Unit cell:
a: 103.885Å b: 103.885Å c: 259.929Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.239 0.239 0.298
Expression system: Escherichia coli

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